STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
csdNitrogen fixation protein (nifS-1); Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (404 aa)    
Predicted Functional Partners:
TP_0615
Nitrogen fixation protein (nifU); Similar to GB:U00013 PID:466875 PID:2398702 percent identity: 32.43; identified by sequence similarity; putative.
 
 0.999
sufD
Conserved hypothetical protein; Similar to GB:U00013 PID:466874 PID:2398705 percent identity: 25.33; identified by sequence similarity; putative.
 
 
 0.987
sufB
Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 52.16; identified by sequence similarity; putative.
 
 
 0.985
sufC
ABC transporter, ATP-binding protein; Similar to PID:1001734 PID:1001706 percent identity: 49.38; identified by sequence similarity; putative.
 
  
 0.982
trxB
Thioredoxin reductase (trxB); Similar to GB:AL009126 percent identity: 46.10; identified by sequence similarity; putative.
  
 
  0.931
nifS
Nitrogen fixation protein (nifS-2); Similar to GB:M86823 SP:Q01179 GB:U22347 PID:151968 percent identity: 38.19; identified by sequence similarity; putative.
 
  
 0.801
TP_0939
Pyruvate oxidoreductase; Similar to PID:1001780 SP:P52965 PID:1006618 percent identity: 58.44; identified by sequence similarity; putative.
  
  
 0.732
glyA
Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.721
TP_0445
4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme (thiJ); Similar to GB:AE000783 percent identity: 31.82; identified by sequence similarity; putative.
    
  0.665
TP_0935
Similar to GB:X65195 PID:295180 PID:48001 percent identity: 37.77; identified by sequence similarity; putative.
 
  
  0.629
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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