| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| TP_0102 | dnaN | TP_0102 | TP_0002 | Rep helicase, single-stranded DNA-dependent ATPase (rep); Similar to GB:AE000783 percent identity: 45.60; identified by sequence similarity; putative. | DNA polymerase III, subunit beta (dnaN); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...] | 0.802 |
| TP_0102 | dnaQ | TP_0102 | TP_0643 | Rep helicase, single-stranded DNA-dependent ATPase (rep); Similar to GB:AE000783 percent identity: 45.60; identified by sequence similarity; putative. | DNA polymerase III, subunit epsilon (dnaQ); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease (By similarity). | 0.681 |
| TP_0102 | ligA | TP_0102 | TP_0634 | Rep helicase, single-stranded DNA-dependent ATPase (rep); Similar to GB:AE000783 percent identity: 45.60; identified by sequence similarity; putative. | DNA ligase (lig); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.778 |
| TP_0102 | polA | TP_0102 | TP_0105 | Rep helicase, single-stranded DNA-dependent ATPase (rep); Similar to GB:AE000783 percent identity: 45.60; identified by sequence similarity; putative. | DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.895 |
| TP_0102 | topA | TP_0102 | TP_0394 | Rep helicase, single-stranded DNA-dependent ATPase (rep); Similar to GB:AE000783 percent identity: 45.60; identified by sequence similarity; putative. | DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...] | 0.907 |
| TP_0102 | uvrC | TP_0102 | TP_0472 | Rep helicase, single-stranded DNA-dependent ATPase (rep); Similar to GB:AE000783 percent identity: 45.60; identified by sequence similarity; putative. | Excinuclease ABC, subunit C (uvrC); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.744 |
| TP_0102 | uvrD | TP_0102 | TP_1028 | Rep helicase, single-stranded DNA-dependent ATPase (rep); Similar to GB:AE000783 percent identity: 45.60; identified by sequence similarity; putative. | DNA helicase II (uvrD); Similar to GP:2618592 percent identity: 40.96; identified by sequence similarity; putative. | 0.936 |
| TP_0588 | dnaN | TP_0588 | TP_0002 | Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 22.22; identified by sequence similarity; putative. | DNA polymerase III, subunit beta (dnaN); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...] | 0.996 |
| TP_0588 | dnaQ | TP_0588 | TP_0643 | Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 22.22; identified by sequence similarity; putative. | DNA polymerase III, subunit epsilon (dnaQ); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease (By similarity). | 0.967 |
| TP_0588 | ligA | TP_0588 | TP_0634 | Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 22.22; identified by sequence similarity; putative. | DNA ligase (lig); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.827 |
| TP_0588 | polA | TP_0588 | TP_0105 | Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 22.22; identified by sequence similarity; putative. | DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.709 |
| TP_0588 | topA | TP_0588 | TP_0394 | Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 22.22; identified by sequence similarity; putative. | DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...] | 0.535 |
| TP_0588 | uvrC | TP_0588 | TP_0472 | Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 22.22; identified by sequence similarity; putative. | Excinuclease ABC, subunit C (uvrC); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.830 |
| dnaN | TP_0102 | TP_0002 | TP_0102 | DNA polymerase III, subunit beta (dnaN); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...] | Rep helicase, single-stranded DNA-dependent ATPase (rep); Similar to GB:AE000783 percent identity: 45.60; identified by sequence similarity; putative. | 0.802 |
| dnaN | TP_0588 | TP_0002 | TP_0588 | DNA polymerase III, subunit beta (dnaN); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...] | Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 22.22; identified by sequence similarity; putative. | 0.996 |
| dnaN | dnaQ | TP_0002 | TP_0643 | DNA polymerase III, subunit beta (dnaN); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...] | DNA polymerase III, subunit epsilon (dnaQ); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease (By similarity). | 0.989 |
| dnaN | ligA | TP_0002 | TP_0634 | DNA polymerase III, subunit beta (dnaN); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...] | DNA ligase (lig); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.827 |
| dnaN | polA | TP_0002 | TP_0105 | DNA polymerase III, subunit beta (dnaN); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...] | DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.996 |
| dnaN | topA | TP_0002 | TP_0394 | DNA polymerase III, subunit beta (dnaN); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...] | DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...] | 0.743 |
| dnaN | uvrC | TP_0002 | TP_0472 | DNA polymerase III, subunit beta (dnaN); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...] | Excinuclease ABC, subunit C (uvrC); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.835 |
