STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tlyCHemolysin (tlyC); Similar to GB:AE000783 percent identity: 51.33; identified by sequence similarity; putative. (265 aa)    
Predicted Functional Partners:
ybeY
Conserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
  
    0.892
TP_0028
Hemolysin, putative; Similar to PID:1653594 percent identity: 26.34; identified by sequence similarity; putative.
  
   
 0.846
TP_0651
Conserved hypothetical integral membrane protein; Similar to SP:P46344 percent identity: 31.03; identified by sequence similarity; putative.
       0.836
TP_0648
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 22.78; identified by sequence similarity; putative.
       0.833
serS
seryl-tRNA synthetase (serS); Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).
       0.643
TP_0646
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 24.77; identified by sequence similarity; putative.
       0.620
potA
Spermidine/putrescine ABC transporter, ATP-binding protein (potA); Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
       0.509
potB
Spermidine/putrescine ABC transporter, permease protein (potB); Similar to GB:AE000782 percent identity: 29.22; identified by sequence similarity; putative.
       0.509
potC
Spermidine/putrescine ABC transporter, permease protein (potC); Similar to GB:L42023 SP:P45169 PID:1007355 PID:1221477 PID:1205581 percent identity: 40.16; identified by sequence similarity; putative.
       0.509
ligA
DNA ligase (lig); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
     
 0.487
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.