STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_06945,10-methenyltetrahydrofolate synthetase, putative; Similar to GB:L38928 SP:P49914 PID:886297 percent identity: 30.69; identified by sequence similarity; putative. (225 aa)    
Predicted Functional Partners:
folD
Methylenetetrahydrofolate dehydrogenase (folD); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.949
TP_0982
glpG protein, putative; Similar to GP:606359 percent identity: 29.47; identified by sequence similarity; putative.
  
  
 0.794
fmt
methionyl-tRNA formyltransferase (fmt); Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
     
 0.736
accC
Phosphoribosylglycinamide formyltransferase, putative; Similar to GB:X78962 SP:P39771 PID:534939 GB:AL009126 percent identity: 30.04; identified by sequence similarity; putative.
       0.542
groS
Chaperonin (groES); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
     
 0.529
TP_0693
Predicted coding region TP0693; Hypothetical protein; identified by Glimmer; putative.
       0.518
TP_0361
Lysophosphatidic acid acyltransferase, putative; Similar to GP:2286207 percent identity: 35.20; identified by sequence similarity; putative.
     
 0.470
fklB
Peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB); Similar to GB:U14003 SP:P39311 PID:537048 GB:U00096 PID:1790652 percent identity: 43.46; identified by sequence similarity; putative.
 
 
   0.432
scpA
Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
       0.425
glyA
Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 
 0.420
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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