STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0696Nicotinamidase, putative; Similar to GP:2183283 percent identity: 33.69; identified by sequence similarity; putative. (278 aa)    
Predicted Functional Partners:
pncB
Conserved hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
 
 
 0.847
TP_0697
Predicted coding region TP0697; Hypothetical protein; identified by Glimmer; putative.
     
 0.821
nadE
NH(3)-dependent NAD(+) synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.
  
 
 0.734
nadD
Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
    
 0.714
oadA
Oxaloacetate decarboxylase, subunit alpha (oadA); Similar to GB:J03885 SP:P13187 PID:149289 percent identity: 50.93; identified by sequence similarity; putative.
  
 
 0.671
mtnN
Pfs protein (pfs); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
    
  0.666
gatA
glu-tRNA amidotransferase, subunit A (gatA); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln) (By similarity).
    
  0.666
pgl
Glucose-6-phosphate 1-dehydrogenase, putative; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
  
 
  0.620
gpsA
Glycerol-3-phosphate dehydrogenase (gpsA); Similar to SP:P46919 PID:974332 PID:1146220 GB:AL009126 percent identity: 35.44; identified by sequence similarity; putative; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
  
   0.616
deoD
Purine nucleoside phosphorylase (deoD); Similar to GP:1638807 percent identity: 57.51; identified by sequence similarity; putative.
    
  0.571
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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