STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mrcAPenicillin-binding protein (pbp-2); Similar to GB:AE000783 percent identity: 40.76; identified by sequence similarity; putative. (884 aa)    
Predicted Functional Partners:
dacC
Serine-type D-Ala-D-Ala carboxypeptidase (dacC); Similar to GB:AE000783 percent identity: 30.68; identified by sequence similarity; putative; Belongs to the peptidase S11 family.
     
 0.941
pbp1
Penicillin-binding protein (pbp-1); Similar to GB:AE000783 percent identity: 37.14; identified by sequence similarity; putative.
 
 
 
 0.875
pbp2
Penicillin-binding protein (pbp-3); Similar to GB:AE000783 percent identity: 30.81; identified by sequence similarity; putative.
 
 
 
 0.846
TP_0706
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 36.30; identified by sequence similarity; putative.
 
   
 0.733
TP_0702
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 31.72; identified by sequence similarity; putative.
 
     0.638
uvrB
Excinuclease ABC, subunit B (uvrB); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dis [...]
    
  0.627
TP_0136
Predicted coding region TP0136; Hypothetical protein; identified by Glimmer; putative.
      
 0.613
TP_0548
Predicted coding region TP0548; Hypothetical protein; identified by Glimmer; putative; Belongs to the UPF0164 family.
      
 0.613
TP_0623
Membrane-bound lytic murein transglycosylase D (dniR); Similar to SP:P23931 GB:X60739 PID:1208972 PID:581068 GB:U00096 percent identity: 32.28; identified by sequence similarity; putative.
 
  
 0.555
TP_0864
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 46.01; identified by sequence similarity; putative.
 
     0.526
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.