STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TP_0764Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 24.58; identified by sequence similarity; putative. (391 aa)    
Predicted Functional Partners:
TP_0981
Sensory transduction histidine kinase, putative; Similar to PID:1652841 percent identity: 33.93; identified by sequence similarity; putative.
 
 
 
 0.858
TP_0763
Predicted coding region TP0763; Hypothetical protein; identified by Glimmer; putative.
       0.714
pth
peptidyl-tRNA hydrolase (pth); The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
   
 
 0.519
TP_0073
Predicted coding region TP0073; Hypothetical protein; identified by Glimmer; putative.
 
 
   0.484
rpoE
RNA polymerase sigma-24 factor (rpoE); Similar to PID:699142 percent identity: 27.89; identified by sequence similarity; putative.
    
 
 0.475
TP_0104
5'-nucleotidase (ushA); Similar to GB:L42023 SP:P44569 PID:1003311 PID:1222124 PID:1204463 percent identity: 50.63; identified by sequence similarity; putative.
 
 
   0.472
dedA
dedA protein (dedA); Similar to GB:L42023 SP:P45280 PID:1007908 PID:1221775 PID:1205860 percent identity: 31.97; identified by sequence similarity; putative.
  
   0.465
rpoN
RNA polymerase sigma-54 factor (rpoN); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
   
 
 0.462
mtnN
Pfs protein (pfs); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
   
   0.434
gyrB
DNA gyrase, subunit B (gyrB); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
   0.423
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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