| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| TP_0223 | dnaK | TP_0223 | TP_0216 | Aspartate aminotransferase (tpaaT); Similar to GP:2104501 percent identity: 99.77; identified by sequence similarity; putative. | Heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.440 |
| TP_0223 | glyA | TP_0223 | TP_0329 | Aspartate aminotransferase (tpaaT); Similar to GP:2104501 percent identity: 99.77; identified by sequence similarity; putative. | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.682 |
| TP_0223 | groL | TP_0223 | TP_0030 | Aspartate aminotransferase (tpaaT); Similar to GP:2104501 percent identity: 99.77; identified by sequence similarity; putative. | Heat shock protein (groEL); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | 0.511 |
| TP_0223 | metK | TP_0223 | TP_0794 | Aspartate aminotransferase (tpaaT); Similar to GP:2104501 percent identity: 99.77; identified by sequence similarity; putative. | S-adenosylmethionine synthetase (metK); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.837 |
| TP_0223 | metN | TP_0223 | TP_0120 | Aspartate aminotransferase (tpaaT); Similar to GP:2104501 percent identity: 99.77; identified by sequence similarity; putative. | Amino acid ABC transporter, ATP-binding protein (abc); Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. | 0.527 |
| TP_0289 | glyA | TP_0289 | TP_0329 | Predicted coding region TP0289; Hypothetical protein; identified by Glimmer; putative. | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.796 |
| TP_0289 | metK | TP_0289 | TP_0794 | Predicted coding region TP0289; Hypothetical protein; identified by Glimmer; putative. | S-adenosylmethionine synthetase (metK); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.759 |
| TP_0289 | rsmA | TP_0289 | TP_0337 | Predicted coding region TP0289; Hypothetical protein; identified by Glimmer; putative. | Dimethyladenosine transferase (ksgA); Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.544 |
| dnaK | TP_0223 | TP_0216 | TP_0223 | Heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family. | Aspartate aminotransferase (tpaaT); Similar to GP:2104501 percent identity: 99.77; identified by sequence similarity; putative. | 0.440 |
| dnaK | glyA | TP_0216 | TP_0329 | Heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family. | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.656 |
| dnaK | groL | TP_0216 | TP_0030 | Heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family. | Heat shock protein (groEL); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | 0.997 |
| dnaK | metK | TP_0216 | TP_0794 | Heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family. | S-adenosylmethionine synthetase (metK); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.781 |
| dnaK | msrAB | TP_0216 | TP_0633 | Heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family. | protein-methionine-S-oxide reductase (msrA); Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity). | 0.573 |
| dnaK | pyrG | TP_0216 | TP_0305 | Heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family. | CTP synthase (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.554 |
| glyA | TP_0223 | TP_0329 | TP_0223 | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aspartate aminotransferase (tpaaT); Similar to GP:2104501 percent identity: 99.77; identified by sequence similarity; putative. | 0.682 |
| glyA | TP_0289 | TP_0329 | TP_0289 | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Predicted coding region TP0289; Hypothetical protein; identified by Glimmer; putative. | 0.796 |
| glyA | dnaK | TP_0329 | TP_0216 | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.656 |
| glyA | groL | TP_0329 | TP_0030 | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Heat shock protein (groEL); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | 0.775 |
| glyA | hemK | TP_0329 | TP_0052 | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Protoporphyrinogen oxidase (hemK); Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.785 |
| glyA | metK | TP_0329 | TP_0794 | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | S-adenosylmethionine synthetase (metK); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.894 |
