STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0835Ankyrin, putative; Similar to GB:X56958 SP:Q01485 PID:29491 percent identity: 30.66; identified by sequence similarity; putative. (934 aa)    
Predicted Functional Partners:
TP_0261
Catabolite gene activator, putative; Similar to PID:1653345 percent identity: 30.99; identified by sequence similarity; putative.
 
 0.989
hrpA
ATP-dependent helicase (hrpA); Similar to GB:AE000783 percent identity: 49.18; identified by sequence similarity; putative.
    
 0.964
rpsC
Ribosomal protein S3 (rpsC); Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family.
    
  0.960
metG
methionyl-tRNA synthetase (metG); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
   
 0.955
nadE
NH(3)-dependent NAD(+) synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.
  
 0.950
sbcD
Exonuclease, putative; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.
    
  0.943
TP_0937
Conserved hypothetical protein; Similar to SP:P94559 PID:1770061 GB:AL009126 percent identity: 27.63; identified by sequence similarity; putative.
    
   0.927
dnaK
Heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
 0.908
TP_0330
Cell division protein, putative; Similar to GB:L43967 SP:P47695 PID:1046176 percent identity: 29.18; identified by sequence similarity; putative.
  
 
 0.805
TP_0954
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 24.29; identified by sequence similarity; putative.
  
  0.803
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.