STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
htrA2Periplasmic serine protease DO (htrA-2); Similar to GB:AE000783 percent identity: 41.83; identified by sequence similarity; putative. (485 aa)    
Predicted Functional Partners:
TP_0546
Periplasmic serine protease, putative; Similar to GB:L20127 PID:310329 percent identity: 37.30; identified by sequence similarity; putative.
  
  
 
0.945
TP_0261
Catabolite gene activator, putative; Similar to PID:1653345 percent identity: 30.99; identified by sequence similarity; putative.
   
 0.577
rplI
Ribosomal protein L9 (rplI); Binds to the 23S rRNA.
 
 
   0.575
map
Methionine aminopeptidase (map); Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
  
   0.570
TP_0468
Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 28.43; identified by sequence similarity; putative.
   
 0.563
dnaK
Heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.561
TP_0835
Ankyrin, putative; Similar to GB:X56958 SP:Q01485 PID:29491 percent identity: 30.66; identified by sequence similarity; putative.
  
  0.551
fklB
Peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB); Similar to GB:U14003 SP:P39311 PID:537048 GB:U00096 PID:1790652 percent identity: 43.46; identified by sequence similarity; putative.
   
 
 0.546
rplY
General stress protein (ctc); This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
  
   0.543
rpsF
Ribosomal protein S6 (rpsF); Binds together with S18 to 16S ribosomal RNA.
   
   0.529
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.