STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0876Conserved hypothetical protein; Similar to GB:U00096 SP:P76256 PID:1736440 PID:1736446 PID:1788109 percent identity: 32.58; identified by sequence similarity; putative. (221 aa)    
Predicted Functional Partners:
tsaE
Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity).
 
 
 0.996
tsaD
O-sialoglycoprotein endopeptidase (gcp); Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.
 
 
 0.970
TP_0874
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 35.37; identified by sequence similarity; putative.
     
 0.837
TP_0877
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 31.09; identified by sequence similarity; putative.
     
 0.821
udg
DNA polymerase, bacteriophage-type; Similar to GB:AE000782 percent identity: 44.38; identified by sequence similarity; putative.
  
    0.757
birA
biotin--acetyl-CoA-carboxylase ligase (birA); Similar to GP:1877334 percent identity: 28.89; identified by sequence similarity; putative.
   
    0.696
TP_0873
Predicted coding region TP0873; Hypothetical protein; identified by Glimmer; putative.
       0.686
fliD
Flagellar filament cap protein (fliD); Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity).
       0.667
sua5
Conserved hypothetical protein; Similar to SP:Q10618 PID:1322425 percent identity: 35.84; identified by sequence similarity; putative; Belongs to the SUA5 family.
     
 0.573
amiC
N-acetylmuramoyl-L-alanine amidase (amiA); Similar to SP:P36548 GB:X75413 PID:453968 GB:U00096 PID:1788776 percent identity: 30.74; identified by sequence similarity; putative.
  
 
 0.535
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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