STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TP_0894Conserved hypothetical protein; Similar to PID:1652748 percent identity: 36.70; identified by sequence similarity; putative. (340 aa)    
Predicted Functional Partners:
trmB
Conserved hypothetical protein; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
  
  
 0.803
TP_0895
Predicted coding region TP0895; Hypothetical protein; identified by Glimmer; putative.
 
     0.800
recB
ATP-dependent nuclease, subunit A, putative; Similar to GB:M63489 SP:P23478 PID:142440 PID:2145362 PID:2226192 percent identity: 29.14; identified by sequence similarity; putative; Belongs to the helicase family. UvrD subfamily.
       0.722
TP_0896
Predicted coding region TP0896; Hypothetical protein; identified by Glimmer; putative.
       0.714
TP_0897
Tpr protein K (tprK); Similar to GP:2196926 percent identity: 40.87; identified by sequence similarity; putative.
       0.714
TP_0899
Predicted coding region TP0899; Hypothetical protein; identified by Glimmer; putative.
       0.714
TP_0900
Predicted coding region TP0900; Hypothetical protein; identified by Glimmer; putative.
       0.714
norM
Conserved hypothetical integral membrane protein; Similar to GB:AE000783 percent identity: 24.31; identified by sequence similarity; putative.
  
    0.616
topA
DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...]
   
   0.602
TP_0902
Carboxylesterase (est); Similar to GB:D12681 SP:Q06174 PID:216314 percent identity: 27.43; identified by sequence similarity; putative.
       0.509
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.