STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0894Conserved hypothetical protein; Similar to PID:1652748 percent identity: 36.70; identified by sequence similarity; putative. (340 aa)    
Predicted Functional Partners:
trmB
Conserved hypothetical protein; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
  
  
 0.817
TP_0895
Predicted coding region TP0895; Hypothetical protein; identified by Glimmer; putative.
 
     0.801
recB
ATP-dependent nuclease, subunit A, putative; Similar to GB:M63489 SP:P23478 PID:142440 PID:2145362 PID:2226192 percent identity: 29.14; identified by sequence similarity; putative; Belongs to the helicase family. UvrD subfamily.
       0.723
TP_0896
Predicted coding region TP0896; Hypothetical protein; identified by Glimmer; putative.
       0.714
TP_0897
Tpr protein K (tprK); Similar to GP:2196926 percent identity: 40.87; identified by sequence similarity; putative.
       0.714
TP_0899
Predicted coding region TP0899; Hypothetical protein; identified by Glimmer; putative.
       0.714
TP_0900
Predicted coding region TP0900; Hypothetical protein; identified by Glimmer; putative.
       0.714
topA
DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...]
   
   0.637
norM
Conserved hypothetical integral membrane protein; Similar to GB:AE000783 percent identity: 24.31; identified by sequence similarity; putative.
  
    0.616
rpsO
Ribosomal protein S15 (rpsO); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
   
   0.534
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.