STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
norMConserved hypothetical integral membrane protein; Similar to GB:AE000783 percent identity: 24.31; identified by sequence similarity; putative. (470 aa)    
Predicted Functional Partners:
cmk
Ribosomal protein S1 (rpsA); Similar to SP:P02349 GB:V00342 GB:V00352 GB:X04864 PID:42837 percent identity: 36.77; identified by sequence similarity; putative.
  
    0.860
gap
Glyceraldehyde 3-phosphate dehydrogenase (gap); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
  
  
 0.857
macA
Membrane fusion protein, putative; Similar to GB:L42023 PID:1005989 PID:1220998 PID:1205141 SP:Q57500 percent identity: 25.88; identified by sequence similarity; putative.
      
 0.716
recB
ATP-dependent nuclease, subunit A, putative; Similar to GB:M63489 SP:P23478 PID:142440 PID:2145362 PID:2226192 percent identity: 29.14; identified by sequence similarity; putative; Belongs to the helicase family. UvrD subfamily.
       0.688
msrAB
protein-methionine-S-oxide reductase (msrA); Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
     
 0.676
TP_0896
Predicted coding region TP0896; Hypothetical protein; identified by Glimmer; putative.
       0.651
TP_0897
Tpr protein K (tprK); Similar to GP:2196926 percent identity: 40.87; identified by sequence similarity; putative.
       0.651
TP_0899
Predicted coding region TP0899; Hypothetical protein; identified by Glimmer; putative.
       0.651
TP_0900
Predicted coding region TP0900; Hypothetical protein; identified by Glimmer; putative.
       0.651
TP_0902
Carboxylesterase (est); Similar to GB:D12681 SP:Q06174 PID:216314 percent identity: 27.43; identified by sequence similarity; putative.
       0.645
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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