STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ndhNADH oxidase; Similar to PID:1199958 percent identity: 61.21; identified by sequence similarity; putative. (445 aa)    
Predicted Functional Partners:
TP_0404
Predicted coding region TP0404; Hypothetical protein; identified by Glimmer; putative.
   
 0.847
trxB
Thioredoxin reductase (trxB); Similar to GB:AL009126 percent identity: 46.10; identified by sequence similarity; putative.
    
 0.831
nadE
NH(3)-dependent NAD(+) synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.
   
 
 0.817
TP_0939
Pyruvate oxidoreductase; Similar to PID:1001780 SP:P52965 PID:1006618 percent identity: 58.44; identified by sequence similarity; putative.
  
 
 0.805
glyA
Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.803
gltD
Glutamate synthase (gltA); Similar to GP:2244618 percent identity: 48.79; identified by sequence similarity; putative.
   
 0.800
pepP
Similar to GP:2584787 percent identity: 37.52; identified by sequence similarity; putative.
    
 0.746
TP_0736
Hydrogenase, gamma chain (hydG); Similar to GB:L77117 PID:1592091 percent identity: 36.32; identified by sequence similarity; putative.
     
 0.738
TP_0223
Aspartate aminotransferase (tpaaT); Similar to GP:2104501 percent identity: 99.77; identified by sequence similarity; putative.
   
 
 0.733
rpsE
Ribosomal protein S5 (rpsE); With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family.
   
   0.716
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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