STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lepB2Signal peptidase I, putative; Similar to GB:X75604 SP:P42668 PID:580781 percent identity: 42.19; identified by sequence similarity; putative; Belongs to the peptidase S26 family. (512 aa)    
Predicted Functional Partners:
lepB1
Signal peptidase I (sip); Similar to GB:AL009126 percent identity: 34.93; identified by sequence similarity; putative; Belongs to the peptidase S26 family.
 
  
  0.937
atpE
V-type ATPase, subunit E, putative; Produces ATP from ADP in the presence of a proton gradient across the membrane.
  
  
  0.855
lepA
GTP-binding membrane protein (lepA); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
  
 
 0.739
TP_0534
Predicted coding region TP0534; Hypothetical protein; identified by Glimmer; putative.
    
  0.703
topA
DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...]
     
 0.641
metG
methionyl-tRNA synthetase (metG); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.607
TP_0622
Predicted coding region TP0622; Hypothetical protein; identified by Glimmer; putative.
 
     0.594
TP_0304
Predicted coding region TP0304; Hypothetical protein; identified by Glimmer; putative.
  
     0.587
ntpK
V-type ATPase, subunit K (atpK-1); Similar to GB:AE000783 percent identity: 53.96; identified by sequence similarity; putative.
    
 0.582
tpn39b
Basic membrane protein (tpn39b); Similar to GB:M17716 SP:P29725 PID:155055 percent identity: 100.00; identified by sequence similarity; putative.
  
  
 0.582
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.