STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
rpeRibulose-phosphate 3-epimerase (cfxE); Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family. (218 aa)    
Predicted Functional Partners:
tkt
Transketolase A (tktA); Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
 
 0.993
rpiA
Ribose 5-phosphate isomerase (rpiA); Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
  
 0.984
gnd
Phosphogluconate dehydrogenase (gnd); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
   
 0.981
TP_0295
Carhohydrate kinase (xylB); Similar to GB:AE000783 percent identity: 28.85; identified by sequence similarity; putative.
    
 0.975
TP_0939
Pyruvate oxidoreductase; Similar to PID:1001780 SP:P52965 PID:1006618 percent identity: 58.44; identified by sequence similarity; putative.
    
 0.970
fliS
Flagellar protein (fliS); Similar to GB:Z31376 SP:P39739 PID:499382 PID:1762346 GB:AL009126 percent identity: 34.48; identified by sequence similarity; putative.
   
 
 0.901
zwf
Glucose-6-phosphate 1-dehydrogenase (zwf); Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.
  
 
 0.893
prs
Phosphoribosyl pyrophosphate synthetase (prs); Similar to GB:AE000783 percent identity: 44.86; identified by sequence similarity; putative; Belongs to the ribose-phosphate pyrophosphokinase family.
  
 
 0.861
ispDF
Conserved hypothetical protein; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
  
 
 0.825
TP_0667
Uridine kinase (udk); Similar to SP:Q59190 PID:1405442 GB:AE000783 percent identity: 28.33; identified by sequence similarity; putative.
    
 0.796
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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