STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TP_0952Lipase, putative; Similar to GB:U03114 PID:416204 percent identity: 28.74; identified by sequence similarity; putative. (345 aa)    
Predicted Functional Partners:
TP_0304
Predicted coding region TP0304; Hypothetical protein; identified by Glimmer; putative.
 
     0.745
TP_0622
Predicted coding region TP0622; Hypothetical protein; identified by Glimmer; putative.
  
     0.744
TP_0220
Anti-sigma F factor antagonist (spoIIAA-1); Similar to GB:M25260 SP:P26777 PID:304171 percent identity: 29.35; identified by sequence similarity; putative; Belongs to the anti-sigma-factor antagonist family.
  
     0.715
TP_0920
Predicted coding region TP0920; Hypothetical protein; identified by Glimmer; putative.
 
     0.715
TP_0095
Predicted coding region TP0095; Hypothetical protein; identified by Glimmer; putative.
  
     0.705
TP_0835
Ankyrin, putative; Similar to GB:X56958 SP:Q01485 PID:29491 percent identity: 30.66; identified by sequence similarity; putative.
  
 
   0.693
TP_0574
Carboxypeptidase, 47 kDa; A possible D,D-carboxypeptidase, that releases amino acids sequentially from a proteins C-terminus. Has zinc-dependent carboxypeptidase activity on synthetic depsipeptide substrates. May serve to decrease cross-linking of peptidoglycan, promoting the highly sinusous motility of this spirochaete (Probable). Overexpression of the whole protein in E.coli leads to aberrant cell morphology and extrusion of the cytoplasm, while overexpression of a construct with the first 62 resides of the protein fused to PhoA does have this effect, suggesting the whole protein, no [...]
     
  0.690
TP_0840
Conserved hypothetical integral membrane protein; Similar to GB:AE000782 percent identity: 25.96; identified by sequence similarity; putative.
 
     0.660
TP_0481
Predicted coding region TP0481; Hypothetical protein; identified by Glimmer; putative.
  
     0.630
TP_0956
Predicted coding region TP0956; Hypothetical protein; identified by Glimmer; putative.
 
     0.603
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.