STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0954Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 24.29; identified by sequence similarity; putative. (478 aa)    
Predicted Functional Partners:
dnaK
Heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.960
htpG
Heat shock protein 90 (htpG); Molecular chaperone. Has ATPase activity.
   
 0.958
alaS
alanyl-tRNA synthetase (alaS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity).
   
  0.941
TP_0460
Predicted coding region TP0460; Hypothetical protein; identified by Glimmer; putative.
 
  
  0.843
TP_0485
Adenylate cyclase; Similar to GP:1754638 percent identity: 40.99; identified by sequence similarity; putative.
   
  0.842
TP_0468
Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 28.43; identified by sequence similarity; putative.
 
  
  0.822
TP_0471
Predicted coding region TP0471; Hypothetical protein; identified by Glimmer; putative.
 
  
  0.816
TP_0835
Ankyrin, putative; Similar to GB:X56958 SP:Q01485 PID:29491 percent identity: 30.66; identified by sequence similarity; putative.
  
  0.803
TP_0622
Predicted coding region TP0622; Hypothetical protein; identified by Glimmer; putative.
 
  
 0.770
rpoA
DNA-directed RNA polymerase, alpha subunit (rpoA); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
  0.756
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.