STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0963Conserved hypothetical integral membrane protein; Similar to GB:AL009126 percent identity: 31.84; identified by sequence similarity; putative. (409 aa)    
Predicted Functional Partners:
TP_0964
ABC transporter, ATP-binding protein; Similar to GB:AL009126 percent identity: 49.32; identified by sequence similarity; putative.
 0.999
lolD
ABC transporter, ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
 0.997
macA
Membrane fusion protein, putative; Similar to GB:L42023 PID:1005989 PID:1220998 PID:1205141 SP:Q57500 percent identity: 25.88; identified by sequence similarity; putative.
 
 
 0.997
TP_0962
Conserved hypothetical integral membrane protein; Similar to GB:AL009126 percent identity: 28.89; identified by sequence similarity; putative.
 
  
0.962
metN
Amino acid ABC transporter, ATP-binding protein (abc); Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
 
      0.794
TP_0966
Predicted coding region TP0966; Hypothetical protein; identified by Glimmer; putative; Belongs to the TP096X family.
     
 0.788
TP_0969
Predicted coding region TP0969; Hypothetical protein; identified by Glimmer; putative; Belongs to the TP096X family.
     
 0.674
TP_0968
Predicted coding region TP0968; Hypothetical protein; identified by Glimmer; putative; Belongs to the TP096X family.
     
 0.666
TP_0967
Predicted coding region TP0967; Hypothetical protein; identified by Glimmer; putative; Belongs to the TP096X family.
     
 0.642
topA
DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...]
     
 0.629
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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