STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0986Conserved hypothetical integral membrane protein; Similar to GB:AE000511 PID:2314395 percent identity: 30.69; identified by sequence similarity; putative. (294 aa)    
Predicted Functional Partners:
TP_0107
licC protein (licC); Similar to GB:L42023 PID:1007733 PID:1221685 PID:1205774 PID:1574381 percent identity: 29.03; identified by sequence similarity; putative.
  
  
 0.712
pepP
Similar to GP:2584787 percent identity: 37.52; identified by sequence similarity; putative.
    
  0.698
aspS
aspartyl-tRNA synthetase (aspS); Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
       0.645
htpG
Heat shock protein 90 (htpG); Molecular chaperone. Has ATPase activity.
   
   0.616
secY
Preprotein translocase subunit (secY); The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
   
   0.610
fadD1
long-chain-fatty-acid--CoA ligase; Similar to GB:AE000783 percent identity: 39.55; identified by sequence similarity; putative.
      
 0.579
TP_0136
Predicted coding region TP0136; Hypothetical protein; identified by Glimmer; putative.
   
   0.577
TP_0405
mcbG protein, putative; Similar to SP:P05530 GB:X07875 PID:41983 percent identity: 23.94; identified by sequence similarity; putative.
   
   0.577
TP_0381
Predicted coding region TP0381; Hypothetical protein; identified by Glimmer; putative.
      
 0.573
mgtE
Mg2+ transport protein (mgtE); Acts as a magnesium transporter.
   
 
 0.473
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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