STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_0116Oxygen-independent coproporphyrinogen III oxidase; Similar to GB:L19201 SP:P32131 GB:X82073 PID:1220106 PID:304972; identified by sequence similarity; putative; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (480 aa)    
Predicted Functional Partners:
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 
 0.881
VC_2755
Protoporphyrinogen oxidase; Similar to GB:M87049 SP:P27863 GB:X68660 PID:148250 PID:581103; identified by sequence similarity; putative.
    
 0.821
VC_1442
Cytochrome c oxidase, subunit CcoN; Similar to SP:P98059 PID:556813; identified by sequence similarity; putative; Belongs to the heme-copper respiratory oxidase family.
 
  
 0.800
ompW
Outer membrane protein OmpW; Similar to SP:P17266 PID:48376 PID:2199526; identified by sequence similarity; putative.
 
  
 0.782
VC_1441
Cytochrome c oxidase, subunit CcoO; Similar to PID:1377866; identified by sequence similarity; putative.
 
  
 0.767
VC_0036
FixG-related protein; Similar to PID:2398782; identified by sequence similarity; putative.
 
  
 0.745
hemF
Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX.
    
 0.682
VC_1439
Cytochrome c oxidase, subunit CcoP; C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
 
  
 0.666
VC_0113
Methyltransferase-related protein; Similar to SP:P37431 PID:295895; identified by sequence similarity; putative.
     
 0.612
VC_0455
Oxygen-independent coproporphyrinogen III oxidase, putative; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
  
  
0.601
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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