STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (317 aa)    
Predicted Functional Partners:
VC_2561
uroporphyrin-III C-methyltransferase; Similar to SP:P11098 GB:X14202 PID:581142 PID:606302 GB:U00096; identified by sequence similarity; putative; Belongs to the precorrin methyltransferase family.
 
 0.997
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 0.995
VC_0105
Delta-aminolevulinic acid dehydratase; Similar to PID:1009431 SP:Q59643; identified by sequence similarity; putative; Belongs to the ALAD family.
 
 0.993
VC_0119
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 0.992
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.984
hemL
Glutamate-1-semialdehyde 2,1-aminomutase; Similar to GB:D26562 SP:P23893 GB:X53696 PID:41621 PID:473813; identified by sequence similarity; putative.
 
  
 0.943
VC_1363
Siroheme synthase component enzyme; Similar to PID:576655; identified by sequence similarity; putative.
 
 0.930
VC_0118
uroporphyrin-III C-methyltransferase, putative; Similar to GB:M87049 SP:P09127 GB:X12614 GB:X13406 PID:148202; identified by sequence similarity; putative.
  
 
 0.920
rsgA
Conserved hypothetical protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
     
 0.744
VC_0117
hemY protein; Similar to GB:M87049 SP:P09128 GB:X12614 PID:148201 PID:41669; identified by sequence similarity; putative.
  
  
 0.725
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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