Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cdpAGGDEF family protein; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP). Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V.cholerae, and is proposed to play an important role in the transition from persistence in the environment to survival in the host. CdpA functions as a repressor of biofilm formation but has no effect on colonization of the infant mouse small intestine. Does not possess diguanylate cyclase (DGC) a [...] (829 aa)    
Predicted Functional Partners:
VC_2370
Sensory box/GGDEF family protein; Similar to PID:1652133; identified by sequence similarity; putative.
 
 
 0.970
VC_1349
Sensory box sensor histidine kinase/response regulator; Similar to PID:1653075; identified by sequence similarity; putative.
  
 
 0.945
VC_2369
Sensor histidine kinase FexB; Similar to SP:P22763 GB:X53315 PID:40951 PID:606149 GB:U00096; identified by sequence similarity; putative.
  
 
 0.945
VC_A0697
Sensory box/GGDEF family protein; Similar to PID:1001780 PID:1001841; identified by sequence similarity; putative.
 
 
 0.926
vdcA
GGDEF family protein; Diguanylate cyclase (DGC) that catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Is involved in the modulation of intracellular c-di-GMP levels. Cyclic- di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V.cholerae, and is proposed to play an important role in the transition from persistence in the environment to survival in the host. Overexpression of vdcA results in increased biofilm formation, and reduced motility and virulence.
 
 
 0.919
VC_2453
Sensor histidine kinase/response regulator; Similar to GB:D10888 SP:P26607 PID:216535 PID:882680 GB:U00096; identified by sequence similarity; putative.
  
  
 0.908
VC_A0939
Sensory box/GGDEF family protein; Similar to PID:1001780 PID:1001789; identified by sequence similarity; putative.
 
 
 0.905
VC_A1083
Conserved hypothetical protein; Identified by Glimmer2; putative.
 
  
 0.901
VC_1653
Sensory box sensor histidine kinase/response regulator VieS; Similar to GP:3123890; identified by sequence similarity; putative.
  
  
 0.900
VC_0398
MSHA biogenesis protein MshH; Similar to SP:P13518 GB:M22055 PID:606192 PID:1128966 GB:U00096; identified by sequence similarity; putative.
 
  
 0.885
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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