Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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cdgJConserved hypothetical protein; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP). Positively regulates motility and negatively regulates biofilm formation. (432 aa)    
Predicted Functional Partners:
VC_0136
Conserved hypothetical protein; Involved in positive regulation of motility and negative regulation of biofilm formation.
       0.790
mbaA
c-di-GMP phosphodiesterase A-related protein; Plays an essential role in the maintenance and the formation of the three-dimensional structure of the biofilms at the later stages of their development. Absence of mbaA promotes the accumulation of larger amount of biomass on the surfaces at later stage of development, results in the overproduction of an extracellular polymeric substance that accumulates in the matrix of biofilms. This yields biofilms lacking the typical structure consisting of pillars of cells separated by fluid filled channels.
  
   
 0.590
VC_0135
Lysophospholipase L2; Similar to PID:1449198; identified by sequence similarity; putative.
       0.580
VC_1885
Hypothetical protein; Identified by Glimmer2; putative.
 
   
 0.449
cdpA
GGDEF family protein; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP). Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V.cholerae, and is proposed to play an important role in the transition from persistence in the environment to survival in the host. CdpA functions as a repressor of biofilm formation but has no effect on colonization of the infant mouse small intestine. Does not possess diguanylate cyclase (DGC) a [...]
 
   
 0.440
VC_0134
Conserved hypothetical protein; Identified by Glimmer2; putative.
       0.419
VC_2133
Flagellar M-ring protein FliF; The M ring may be actively involved in energy transduction. Belongs to the FliF family.
  
     0.407
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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