STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_0161Transcriptional activator IlvY; Similar to GB:L42023 SP:P44821 PID:1005575 PID:1220765 PID:1204932; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family. (298 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
   
 0.734
VC_A0833
Transcriptional regulator, LysR family; Similar to GB:AE000657; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.703
VC_A0964
Glycine cleavage operon activator, putative; Similar to GB:L42023 SP:P45099 PID:1007064 PID:1221317 PID:1205437; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.629
VC_1049
Transcriptional regulator, LysR family; Similar to GP:1139588; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.606
VC_1955
Transcriptional regulator, LysR family; Similar to PID:1652912; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.538
VC_A0982
Transcriptional regulator, LysR family; Similar to PID:1652750; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.532
VC_0732
Transcriptional regulator, LysR family; Similar to PID:887385 SP:P52667 PID:1359475; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.519
VC_A0635
Transcriptional regulator, LysR family; Similar to GB:U00096 PID:1788100; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.502
VC_A0889
Transcriptional regulator, LysR family; Similar to PID:924993 SP:P52689; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.463
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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