Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
capVPatatin-related protein; Phospholipase that is activated upon binding to the cyclic dinucleotide (CDN) second messenger 3',3'-cyclic GMP-AMP (3',3'-cGAMP). Thus, degrades phosphatidylethanolamine (PE) and phosphatidylglycerol (PG), the major phospholipids in the cell membrane of V.cholerae, releasing 16:1 and 18:1 free fatty acids. (355 aa)    
Predicted Functional Partners:
VC_0180
Conserved hypothetical protein; Identified by Glimmer2; putative.
 
   
 0.966
dncV
Hypothetical protein; Catalyzes the synthesis of 3'3'-cyclic GMP-AMP (3'3'-cGAMP) from GTP and ATP, a second messenger in cell signal transduction. Is also able to produce c-di-AMP and c-di-GMP from ATP and GTP, respectively; however, 3'3'-cGAMP is the dominant molecule produced by DncV in vivo, contrary to the 2'3'-cGAMP produced by eukaryotes. Is required for efficient V.cholerae intestinal colonization, and down- regulates the colonization-influencing process of chemotaxis. Is not active with dATP, TTP, UTP, and CTP. Controls the activity of cGAMP- activated phospholipase CapV, a pa [...]
     
 0.912
VC_0181
Conserved hypothetical protein; Identified by Glimmer2; putative.
     
 0.784
VC_A0236
Hypothetical protein; Identified by Glimmer2; putative.
   
   0.617
VC_1944
PvcB protein; Similar to GP:3212173; identified by sequence similarity; putative.
  
     0.573
VC_0283
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.485
VC_A0926
Transcriptional regulator, AraC/XylS family; Similar to GP:2906236; identified by sequence similarity; putative.
  
     0.449
VC_2622
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.432
VC_A0284
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.409
VC_0239
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
    0.401
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.