STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
capVPatatin-related protein; Phospholipase that is activated upon binding to the cyclic dinucleotide (CDN) second messenger 3',3'-cyclic GMP-AMP (3',3'-cGAMP). Thus, degrades phosphatidylethanolamine (PE) and phosphatidylglycerol (PG), the major phospholipids in the cell membrane of V.cholerae, releasing 16:1 and 18:1 free fatty acids. (355 aa)    
Predicted Functional Partners:
VC_0180
Conserved hypothetical protein; Identified by Glimmer2; putative.
 
   
 0.961
dncV
Hypothetical protein; Catalyzes the synthesis of 3'3'-cyclic GMP-AMP (3'3'-cGAMP) from GTP and ATP, a second messenger in cell signal transduction. Is also able to produce c-di-AMP and c-di-GMP from ATP and GTP, respectively; however, 3'3'-cGAMP is the dominant molecule produced by DncV in vivo, contrary to the 2'3'-cGAMP produced by eukaryotes. Is required for efficient V.cholerae intestinal colonization, and down- regulates the colonization-influencing process of chemotaxis. Is not active with dATP, TTP, UTP, and CTP. Controls the activity of cGAMP- activated phospholipase CapV, a pa [...]
     
 0.895
VC_0181
Conserved hypothetical protein; Identified by Glimmer2; putative.
     
 0.870
VC_A0510
Hypothetical protein; Identified by Glimmer2; putative.
     
 0.606
VC_A0136
Glycerophosphoryl diester phosphodiesterase; Similar to SP:P09394 GB:X56907 GB:Y00536 PID:41581 PID:902489; identified by sequence similarity; putative.
  
  
 0.603
VC_1944
PvcB protein; Similar to GP:3212173; identified by sequence similarity; putative.
  
     0.573
VC_0315
CDP-diacylglycerol--serine O-phosphatidyltransferase; Similar to GB:M58699 SP:P23830 PID:147389 GB:U00096 PID:1788940; identified by sequence similarity; putative.
     
 0.515
clsA
Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
     
 0.515
VC_1554
Glycerophosphoryl diester phosphodiesterase, putative; Similar to SP:P54527 PID:1303930 GB:AL009126; identified by sequence similarity; putative.
     
 0.514
VC_0283
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.485
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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