Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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dncVHypothetical protein; Catalyzes the synthesis of 3'3'-cyclic GMP-AMP (3'3'-cGAMP) from GTP and ATP, a second messenger in cell signal transduction. Is also able to produce c-di-AMP and c-di-GMP from ATP and GTP, respectively; however, 3'3'-cGAMP is the dominant molecule produced by DncV in vivo, contrary to the 2'3'-cGAMP produced by eukaryotes. Is required for efficient V.cholerae intestinal colonization, and down- regulates the colonization-influencing process of chemotaxis. Is not active with dATP, TTP, UTP, and CTP. Controls the activity of cGAMP- activated phospholipase CapV, a pa [...] (436 aa)    
Predicted Functional Partners:
capV
Patatin-related protein; Phospholipase that is activated upon binding to the cyclic dinucleotide (CDN) second messenger 3',3'-cyclic GMP-AMP (3',3'-cGAMP). Thus, degrades phosphatidylethanolamine (PE) and phosphatidylglycerol (PG), the major phospholipids in the cell membrane of V.cholerae, releasing 16:1 and 18:1 free fatty acids.
     
 0.912
VC_0180
Conserved hypothetical protein; Identified by Glimmer2; putative.
     
 0.885
VC_0181
Conserved hypothetical protein; Identified by Glimmer2; putative.
       0.807
VC_A0681
Conserved hypothetical protein; Phosphodiesterase (PDE) that catalyzes the hydrolysis of 3'3'-cyclic GMP-AMP (3'3'-cGAMP), leading to linear 5'-pApG. Also displays 5'-nucleotidase activity, further hydrolyzing 5'-pApG to 5'-ApG. Counteracts the function of the 3'3'-cGAMP synthase DncV, and is involved in the modulation of intracellular 3'3'-cGAMP levels. Enhances bacterial chemotaxis and inhibits intestinal colonization in vivo. Thus exerts a crucial role in regulating bacterial infectivity through catalyzing 3'3'-cGAMP degradation. Is specific for 3'3'-cGAMP since it cannot degrade ot [...]
      
 0.548
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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