Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
VC_0183Hypothetical protein; Identified by Glimmer2; putative. (703 aa)    
Predicted Functional Partners:
VC_0182
Hypothetical protein; Identified by Glimmer2; putative.
       0.849
VC_0184
Hypothetical protein; Identified by Glimmer2; putative.
       0.849
VC_0185
Transposase, putative; Similar to SP:P06696 PID:581277 PID:154921; identified by sequence similarity; putative.
     
 0.817
VC_0186
Glutathione reductase; Similar to SP:P06715 GB:M13141 PID:146248 PID:466637 GB:U00096; identified by sequence similarity; putative.
     
 0.603
VC_1531
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.508
rtxA
RTX toxin RtxA; [Multifunctional-autoprocessing repeats-in-toxin]: Precursor of a multifunctional toxin that causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases when translocated into the host cytoplasm. Upon translocation into the host cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain (also named CPD domain): the protease activity is activated upon binding inositol hexakisphosphate (InsP6) present at the host cell membrane and delivers the Cysteine protease domain-containing toxin F3 chain to the host [...]
  
     0.482
VC_2032
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.461
VC_A0422
Conserved hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system.
  
     0.443
rlmJ
Conserved hypothetical protein; Specifically methylates the adenine in position 2030 of 23S rRNA.
       0.428
rtxC
RTX toxin activating protein; Involved in fatty acylation of the protoxin (RtxA) at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP (By similarity).
  
     0.414
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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