STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
murQ1GckR family protein; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. (305 aa)    
Predicted Functional Partners:
murP
PTS system, sucrose-specific IIBC component, putative; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring.
 
 
 0.968
VC_0910
PTS system, trehalose-specific IIBC component; Similar to SP:P36672 GB:U06195 PID:459401 GB:U00096 PID:2367362; identified by sequence similarity; putative.
  
 
 0.864
VC_0995
PTS system, N-acetylglucosamine-specific IIABC component; Similar to GP:2541900; identified by sequence similarity; putative.
  
 
 0.864
VC_2013
PTS system, glucose-specific IIBC component; Similar to GB:J02618 SP:P05053 PID:147393 GB:U00096 PID:1651541; identified by sequence similarity; putative.
  
 
 0.864
VC_A0653
PTS system, sucrose-specific IIBC component; Similar to GB:M76768 SP:P22825 PID:155262; identified by sequence similarity; putative.
  
 
 0.864
anmK
Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family.
   
 0.834
VC_0204
Conserved hypothetical protein; Identified by Glimmer2; putative.
 
  
 0.780
VC_0205
Hypothetical protein; Identified by Glimmer2; putative.
       0.773
nagA
N-acetylglucosamine-6-phosphate deacetylase; Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate.
  
 0.766
gspK
Conserved hypothetical protein; ATP-dependent kinase, which is specific for glucosamine. Does not show kinase activity with any other sugar. Belongs to the eukaryotic-type N-acetylglucosamine kinase family.
 
 
 0.673
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.