Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
kdkAConserved hypothetical protein; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family. (251 aa)    
Predicted Functional Partners:
VC_0233
3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
   
 0.990
VC_0225
Lipopolysaccharide biosynthesis protein, putative; Similar to GB:L42023 PID:1003419 PID:1222185 PID:1204517 PID:1573227; identified by sequence similarity; putative.
 
   
 0.900
VC_0228
Hypothetical protein; Identified by Glimmer2; putative.
       0.776
VC_2044
Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the glutaredoxin family. Monothiol subfamily.
    
 
 0.745
lpxL
Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A).
 
   
 0.602
epsH
General secretion pathway protein H; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane.
  
     0.583
VC_0224
Lipopolysaccharide biosynthesis glycosyltransferase, putative; Similar to GB:L42023 SP:P44029 PID:1005522 PID:1220737 PID:1204904; identified by sequence similarity; putative.
 
     0.569
VC_0115
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
     0.545
VC_2600
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
     0.492
VC_0353
Conserved hypothetical protein; Identified by Glimmer2; putative.
    
   0.462
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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