Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
VC_0278Transcriptional activator CadC, putative; Similar to SP:P23890 GB:M67452 PID:145452 PID:536978 GB:U00096; identified by sequence similarity; putative. (541 aa)    
Predicted Functional Partners:
VC_A0250
Alpha-amylase; Similar to PID:1177849; identified by sequence similarity; putative.
  
     0.658
prtV
Protease; Metalloprotease that exhibits a cytotoxic effect leading to cell death. In host tissues, it could play a role in pathogenesis by modulating the stability of the extracellular matrix components such as fibronectin and fibrinogen. Also able to cleave plasminogen.
  
   
 0.638
VC_0280
Cadaverine/lysine antiporter CadB, putative; Similar to SP:P23891 GB:M67452 GB:M76411 PID:145453 PID:145457; identified by sequence similarity; putative.
  
   
 0.636
VC_A0065
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.606
rtxA
RTX toxin RtxA; [Multifunctional-autoprocessing repeats-in-toxin]: Precursor of a multifunctional toxin that causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases when translocated into the host cytoplasm. Upon translocation into the host cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain (also named CPD domain): the protease activity is activated upon binding inositol hexakisphosphate (InsP6) present at the host cell membrane and delivers the Cysteine protease domain-containing toxin F3 chain to the host [...]
  
     0.591
rtxC
RTX toxin activating protein; Involved in fatty acylation of the protoxin (RtxA) at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP (By similarity).
  
     0.578
VC_1983
Peptidase, putative; Similar to SP:P47788 PID:1871406 PID:565284; identified by sequence similarity; putative.
  
     0.538
VC_1644
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.533
VC_0277
Transcriptional regulator, MerR family; Similar to GB:L29458 SP:P36676 PID:473422 PID:606226 GB:U00096; identified by sequence similarity; putative.
     
 0.528
VC_1317
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
     0.510
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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