Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (359 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.997
hemF
Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX.
 
 0.978
VC_0119
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.958
VC_0116
Oxygen-independent coproporphyrinogen III oxidase; Similar to GB:L19201 SP:P32131 GB:X82073 PID:1220106 PID:304972; identified by sequence similarity; putative; Belongs to the anaerobic coproporphyrinogen-III oxidase family.
 
 
 0.947
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.940
VC_0105
Delta-aminolevulinic acid dehydratase; Similar to PID:1009431 SP:Q59643; identified by sequence similarity; putative; Belongs to the ALAD family.
 
 
 0.933
VC_2561
uroporphyrin-III C-methyltransferase; Similar to SP:P11098 GB:X14202 PID:581142 PID:606302 GB:U00096; identified by sequence similarity; putative; Belongs to the precorrin methyltransferase family.
    
 0.929
VC_0118
uroporphyrin-III C-methyltransferase, putative; Similar to GB:M87049 SP:P09127 GB:X12614 GB:X13406 PID:148202; identified by sequence similarity; putative.
    
 0.904
VC_0333
Transcriptional reguator, TetR family; Similar to GB:X66592 PID:45394; identified by sequence similarity; putative.
     
 0.852
hemL
Glutamate-1-semialdehyde 2,1-aminomutase; Similar to GB:D26562 SP:P23893 GB:X53696 PID:41621 PID:473813; identified by sequence similarity; putative.
 
  
 0.805
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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