Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
VC_0414Hypothetical protein; Identified by Glimmer2; putative. (1252 aa)    
Predicted Functional Partners:
VC_0412
Hypothetical protein; Identified by Glimmer2; putative.
 
   
 0.975
rtxA
RTX toxin RtxA; [Multifunctional-autoprocessing repeats-in-toxin]: Precursor of a multifunctional toxin that causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases when translocated into the host cytoplasm. Upon translocation into the host cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain (also named CPD domain): the protease activity is activated upon binding inositol hexakisphosphate (InsP6) present at the host cell membrane and delivers the Cysteine protease domain-containing toxin F3 chain to the host [...]
  
 
 0.962
VC_0411
MSHA pilin protein MshD; Similar to GB:X77217 PID:673506 PID:673507; identified by sequence similarity; putative.
 
  
 0.930
VC_0409
MSHA pilin protein MshA; Similar to GP:673504; identified by sequence similarity; putative.
 
   
 0.909
VC_0400
MSHA biogenesis protein MshJ; Similar to PID:791156 PID:791154; identified by sequence similarity; putative.
 
   
 0.896
VC_0402
MSHA biogenesis protein MshL; Similar to PID:791156; identified by sequence similarity; putative.
 
  
 0.894
VC_0408
MSHA pilin protein MshB; Similar to GB:X77217 PID:496758; identified by sequence similarity; putative.
 
   
 0.875
VC_0410
MSHA pilin protein MshC; Similar to GB:X77217 PID:496759; identified by sequence similarity; putative.
 
   
 0.875
ftsK
Cell division protein FtsK, putative; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the directi [...]
   
 
 0.875
irgA
Iron-regulated outer membrane virulence protein, TonB receptor family; Involved in the initial step of iron uptake by binding ferric vibriobactin, an iron chelatin siderophore that allows V.cholerae to extract iron from the environment; Belongs to the TonB-dependent receptor family.
   
 
 0.865
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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