STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_0438Conserved hypothetical protein; Identified by Glimmer2; putative. (289 aa)    
Predicted Functional Partners:
VC_0439
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
 0.994
cgtA
GTP1/Obg family protein; Depletion experiments lead to gene down regulation and a dramatic increase in ppGpp levels, like those seen in the stringent response. There is no change in cell morphology in depletion experiments , but cells are very sensitive to the DNA-damaging agent hydroxyurea and are very elongated. Overexpression reduces growth and leads to elongated cells. Overexpression of proteins with C-terminal deletions of 29 or 62 amino acids showed fewer elongated cells. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
       0.835
VC_0440
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
       0.784
rpmA
Ribosomal protein L27; Similar to GB:D13267 SP:P02427 PID:216637 PID:606123 GB:U00096; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL27 family.
       0.692
rplU
Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
       0.676
VC_1576
Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the UPF0267 family.
  
     0.554
VC_A0543
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
     0.517
dcuC
C4-dicarboxylate transporter, anaerobic; Responsible for the transport of C4-dicarboxylates during anaerobic growth; Belongs to the DcuC/DcuD transporter (TC 2.A.61) family.
  
     0.516
VC_1892
Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the UPF0227 family.
  
     0.507
VC_A0205
C4-dicarboxylate transporter, anaerobic; Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane; Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
  
     0.473
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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