STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
irgBIron-regulated virulence regulatory protein IrgB; Transcription activation of the irgA gene. In the presence of sufficient iron, transcription of both irgA and irgB is negatively regulated by a fur-like protein. In low iron conditions, negative regulation of transcription is removed, and production of irgB leads to positive transcriptional activation of irgA (By similarity). (298 aa)    
Predicted Functional Partners:
irgA
Iron-regulated outer membrane virulence protein, TonB receptor family; Involved in the initial step of iron uptake by binding ferric vibriobactin, an iron chelatin siderophore that allows V.cholerae to extract iron from the environment; Belongs to the TonB-dependent receptor family.
 
   
 0.824
VC_1588
Transcriptional regulator, LysR family; Similar to PID:727227 SP:P52666; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
   
 0.771
VC_0787
Transcriptional regulator, LysR family; Similar to SP:P46068 PID:1050466 GB:U00096 PID:1788706 PID:1799763; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.762
VC_A0964
Glycine cleavage operon activator, putative; Similar to GB:L42023 SP:P45099 PID:1007064 PID:1221317 PID:1205437; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.748
VC_A0833
Transcriptional regulator, LysR family; Similar to GB:AE000657; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.736
VC_2636
Transcriptional regulator, LysR family; Similar to PID:1658188; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.670
VC_0732
Transcriptional regulator, LysR family; Similar to PID:887385 SP:P52667 PID:1359475; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.635
VC_2760
Transcriptional regulator, LysR family; Similar to SP:P37598 GB:U00096 PID:1742732 PID:1742742 PID:1787949; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.631
VC_1561
Transcriptional regulator, LysR family; Similar to SP:P10183 PID:150233; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
   
 0.592
VC_A0542
Transcriptional regulator, LysR family; Similar to SP:P32484 PID:405876 PID:466777 GB:U00096 PID:1788481; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.566
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.