Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
VC_0508Hypothetical protein; Identified by Glimmer2; putative. (147 aa)    
Predicted Functional Partners:
VC_0507
Hypothetical protein; Identified by Glimmer2; putative.
       0.784
VC_A0250
Alpha-amylase; Similar to PID:1177849; identified by sequence similarity; putative.
  
     0.712
VC_0509
Hypothetical protein; Identified by Glimmer2; putative.
       0.640
VC_0510
DNA repair protein RadC-related protein; Similar to PID:1208991 GB:U00096 PID:1552815 PID:2367100; identified by sequence similarity; putative; Belongs to the UPF0758 family.
       0.630
VC_0504
Hypothetical protein; Identified by Glimmer2; putative.
     
 0.605
VC_2605
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.521
VC_0506
Hypothetical protein; Identified by Glimmer2; putative.
       0.516
rtxA
RTX toxin RtxA; [Multifunctional-autoprocessing repeats-in-toxin]: Precursor of a multifunctional toxin that causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases when translocated into the host cytoplasm. Upon translocation into the host cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain (also named CPD domain): the protease activity is activated upon binding inositol hexakisphosphate (InsP6) present at the host cell membrane and delivers the Cysteine protease domain-containing toxin F3 chain to the host [...]
  
     0.499
VC_0511
Hypothetical protein; Identified by Glimmer2; putative.
     
 0.480
prtV
Protease; Metalloprotease that exhibits a cytotoxic effect leading to cell death. In host tissues, it could play a role in pathogenesis by modulating the stability of the extracellular matrix components such as fibronectin and fibrinogen. Also able to cleave plasminogen.
  
     0.477
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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