Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
gshAGlutamate--cysteine ligase; Similar to SP:P06980 GB:X03954 PID:581100 GB:U00096 PID:1789044; identified by sequence similarity; putative; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (524 aa)    
Predicted Functional Partners:
gshB
Glutathione synthetase; Similar to SP:P04425 GB:X01666 PID:41625 PID:882476 GB:U00096; identified by sequence similarity; putative.
 
 
 0.977
VC_1494
Aminopeptidase N; Similar to GB:M15273 SP:P04825 GB:M15676 GB:X04020 PID:147142; identified by sequence similarity; putative.
     
 0.922
VC_0194
Gamma-glutamyltranspeptidase; Similar to GB:AL123456; identified by sequence similarity; putative.
    
 0.908
VC_2279
Aminoacyl-histidine dipeptidase; Similar to GB:M34034 SP:P15288 GB:X14790 PID:1208983 PID:147140; identified by sequence similarity; putative.
     
 0.907
pepB
Peptidase B; Probably plays an important role in intracellular peptide degradation.
     
 0.906
pepA
Aminopeptidase A/I; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity).
     
 0.906
ilvE
Branched-chain amino acid amiotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
     
  0.900
pxpA
Conserved hypothetical protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
     
  0.900
VC_A0778
Conserved hypothetical protein; Identified by Glimmer2; putative.
     
  0.900
luxS
Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
     
 0.899
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.