Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
VC_0604Aconitate hydratase 2; Similar to SP:P36683 GB:U00096 PID:2367097; identified by sequence similarity; putative; Belongs to the aconitase/IPM isomerase family. (865 aa)    
Predicted Functional Partners:
VC_2092
Citrate synthase; Similar to GB:J01619 SP:P00891 GB:M28987 GB:M28988 GB:V01501; identified by sequence similarity; putative; Belongs to the citrate synthase family.
  
 
 0.973
VC_1337
Methylcitrate synthase; Similar to GB:U00096 PID:1657529 PID:1786527; identified by sequence similarity; putative; Belongs to the citrate synthase family.
  
 
 0.965
VC_1141
Isocitrate dehydrogenase; Similar to PID:1030696; identified by sequence similarity; putative; Belongs to the monomeric-type IDH family.
 
 
 0.956
VC_2087
2-oxoglutarate dehydrogenase, E1 component; Similar to GB:J01619 SP:P07015 PID:146201 PID:43019 GB:U00096; identified by sequence similarity; putative.
   
  
 0.937
sucC
succinyl-CoA synthase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.925
VC_0736
Isocitrate lyase; Similar to SP:P05313 GB:M20714 GB:M22621 GB:X07543 GB:X12431; identified by sequence similarity; putative.
   
 
 0.923
prpB
Carboxyphosphonoenolpyruvate phosphonomutase; Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage reaction of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.
  
 
 0.922
VC_1339
Conserved hypothetical protein; Identified by Glimmer2; putative.
    
 0.912
VC_1304
Fumarate hydratase, class I, putative; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
 
  
 0.887
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
  
  
 0.886
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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