STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ompUOuter membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. (350 aa)    
Predicted Functional Partners:
VC_2213
Outer membrane protein OmpA; Similar to GP:2641145; identified by sequence similarity; putative; Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
   
 0.920
btuB
Vitamin B12 receptor; Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB; Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
  
 
 0.883
VC_2048
vacJ lipoprotein; Similar to GB:U00096 SP:P76506 PID:1788688 PID:1799744; identified by sequence similarity; putative.
   
 
 0.833
VC_0901
Hypothetical protein; Identified by Glimmer2; putative.
  
 
   0.786
VC_1157
Response regulator; Similar to PID:643672; identified by sequence similarity; putative.
  
 
 
 0.786
toxR
Cholera toxin transcriptional activator; This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT.
  
   
 0.784
VC_0132
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.772
VC_2346
Smp protein, putative; Similar to SP:P18838 GB:M30784 GB:X03046 PID:432633 PID:436177; identified by sequence similarity; putative.
  
   
 0.770
VC_2276
Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the UPF0255 family.
  
    0.767
VC_0425
Hypothetical protein; Identified by Glimmer2; putative.
  
   
 0.765
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.