Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ompUOuter membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. (350 aa)    
Predicted Functional Partners:
toxR
Cholera toxin transcriptional activator; This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT.
  
   
 0.984
VC_1854
Porin, putative; Similar to GP:3377759; identified by sequence similarity; putative.
     
 0.928
VC_A1008
Outer membrane protein, putative; Similar to PID:1658032; identified by sequence similarity; putative.
  
  
 
0.922
VC_0972
Porin, putative; Similar to SP:P24305; identified by sequence similarity; putative.
     
 0.920
btuB
Vitamin B12 receptor; Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB; Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
  
 
 0.822
VC_2346
Smp protein, putative; Similar to SP:P18838 GB:M30784 GB:X03046 PID:432633 PID:436177; identified by sequence similarity; putative.
  
   
 0.809
VC_2213
Outer membrane protein OmpA; Similar to GP:2641145; identified by sequence similarity; putative; Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
   
 0.806
VC_2276
Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the UPF0255 family.
  
  
 0.796
VC_0901
Hypothetical protein; Identified by Glimmer2; putative.
  
 
   0.779
VC_1157
Response regulator; Similar to PID:643672; identified by sequence similarity; putative.
  
   0.779
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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