Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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VC_0638Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (278 aa)    
Predicted Functional Partners:
VC_0593
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Similar to GB:D26562 SP:P26281 GB:L06495 PID:146013 PID:473801; identified by sequence similarity; putative.
 
 0.999
VC_1001
Folylpolyglutamate synthase/dihydrofolate synthase; Similar to GB:M68934 SP:P08192 GB:M32445 PID:146009 PID:146020; identified by sequence similarity; putative; Belongs to the folylpolyglutamate synthase family.
 
 0.998
VC_0524
Dihydroneopterin aldolase FolB, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
 
 0.997
VC_0525
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Similar to GB:D26562 SP:P26281 GB:L06495 PID:146013 PID:473801; identified by sequence similarity; putative.
 
 
 0.995
folE
GTP cyclohydrolase; Similar to GB:U00007 SP:P27511 GB:X63910 PID:312964 PID:405902; identified by sequence similarity; putative.
 
  
 0.979
pabC
4-amino-4-deoxychorismate lyase; Involved in the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate (By similarity).
 
 
 0.946
glmM
Phosphoglucomutase/phosphomannomutase family protein MrsA; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.
  
  
 0.933
ftsH
Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
  
 0.864
guaB
Inosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.710
rlmE
Cell division protein FtsJ; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
  
  
 0.706
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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