node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
VC_1033 | VC_A0530 | VC_1033 | VC_A0530 | Cation transport ATPase, E1-E2 family; Similar to SP:P37617 PID:466605 GB:U00096 PID:1789879; identified by sequence similarity; putative. | Pyruvate-flavoredoxin oxidoreductase; Similar to GB:U00096 PID:1742250 PID:1742256 PID:1787642; identified by sequence similarity; putative. | 0.495 |
VC_1033 | hlyU | VC_1033 | VC_0678 | Cation transport ATPase, E1-E2 family; Similar to SP:P37617 PID:466605 GB:U00096 PID:1789879; identified by sequence similarity; putative. | Transcriptional activator HlyU; Up-regulates the expression of the hemolysin gene, hlyA, and may promote expression of other virulence determinants in vivo. It may have both positive and negative regulator activities. | 0.466 |
VC_A0530 | VC_1033 | VC_A0530 | VC_1033 | Pyruvate-flavoredoxin oxidoreductase; Similar to GB:U00096 PID:1742250 PID:1742256 PID:1787642; identified by sequence similarity; putative. | Cation transport ATPase, E1-E2 family; Similar to SP:P37617 PID:466605 GB:U00096 PID:1789879; identified by sequence similarity; putative. | 0.495 |
VC_A0530 | birA | VC_A0530 | VC_0319 | Pyruvate-flavoredoxin oxidoreductase; Similar to GB:U00096 PID:1742250 PID:1742256 PID:1787642; identified by sequence similarity; putative. | birA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.786 |
VC_A0530 | copA | VC_A0530 | VC_2215 | Pyruvate-flavoredoxin oxidoreductase; Similar to GB:U00096 PID:1742250 PID:1742256 PID:1787642; identified by sequence similarity; putative. | Cation transport ATPase, E1-E2 family; Involved in copper export. | 0.495 |
VC_A0530 | folE | VC_A0530 | VC_A0616 | Pyruvate-flavoredoxin oxidoreductase; Similar to GB:U00096 PID:1742250 PID:1742256 PID:1787642; identified by sequence similarity; putative. | GTP cyclohydrolase; Similar to GB:U00007 SP:P27511 GB:X63910 PID:312964 PID:405902; identified by sequence similarity; putative. | 0.481 |
VC_A0530 | hlyU | VC_A0530 | VC_0678 | Pyruvate-flavoredoxin oxidoreductase; Similar to GB:U00096 PID:1742250 PID:1742256 PID:1787642; identified by sequence similarity; putative. | Transcriptional activator HlyU; Up-regulates the expression of the hemolysin gene, hlyA, and may promote expression of other virulence determinants in vivo. It may have both positive and negative regulator activities. | 0.489 |
VC_A0530 | ndk | VC_A0530 | VC_0756 | Pyruvate-flavoredoxin oxidoreductase; Similar to GB:U00096 PID:1742250 PID:1742256 PID:1787642; identified by sequence similarity; putative. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.498 |
birA | VC_A0530 | VC_0319 | VC_A0530 | birA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Pyruvate-flavoredoxin oxidoreductase; Similar to GB:U00096 PID:1742250 PID:1742256 PID:1787642; identified by sequence similarity; putative. | 0.786 |
birA | folE | VC_0319 | VC_A0616 | birA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | GTP cyclohydrolase; Similar to GB:U00007 SP:P27511 GB:X63910 PID:312964 PID:405902; identified by sequence similarity; putative. | 0.405 |
birA | hlyU | VC_0319 | VC_0678 | birA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Transcriptional activator HlyU; Up-regulates the expression of the hemolysin gene, hlyA, and may promote expression of other virulence determinants in vivo. It may have both positive and negative regulator activities. | 0.521 |
birA | ndk | VC_0319 | VC_0756 | birA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.495 |
cobB | hlyU | VC_1509 | VC_0678 | Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form; Belongs to the sirtuin family. Class III subfamily. | Transcriptional activator HlyU; Up-regulates the expression of the hemolysin gene, hlyA, and may promote expression of other virulence determinants in vivo. It may have both positive and negative regulator activities. | 0.499 |
cobB | nadK | VC_1509 | VC_0853 | Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form; Belongs to the sirtuin family. Class III subfamily. | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.694 |
copA | VC_A0530 | VC_2215 | VC_A0530 | Cation transport ATPase, E1-E2 family; Involved in copper export. | Pyruvate-flavoredoxin oxidoreductase; Similar to GB:U00096 PID:1742250 PID:1742256 PID:1787642; identified by sequence similarity; putative. | 0.495 |
copA | hlyU | VC_2215 | VC_0678 | Cation transport ATPase, E1-E2 family; Involved in copper export. | Transcriptional activator HlyU; Up-regulates the expression of the hemolysin gene, hlyA, and may promote expression of other virulence determinants in vivo. It may have both positive and negative regulator activities. | 0.478 |
folE | VC_A0530 | VC_A0616 | VC_A0530 | GTP cyclohydrolase; Similar to GB:U00007 SP:P27511 GB:X63910 PID:312964 PID:405902; identified by sequence similarity; putative. | Pyruvate-flavoredoxin oxidoreductase; Similar to GB:U00096 PID:1742250 PID:1742256 PID:1787642; identified by sequence similarity; putative. | 0.481 |
folE | birA | VC_A0616 | VC_0319 | GTP cyclohydrolase; Similar to GB:U00007 SP:P27511 GB:X63910 PID:312964 PID:405902; identified by sequence similarity; putative. | birA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.405 |
folE | hlyU | VC_A0616 | VC_0678 | GTP cyclohydrolase; Similar to GB:U00007 SP:P27511 GB:X63910 PID:312964 PID:405902; identified by sequence similarity; putative. | Transcriptional activator HlyU; Up-regulates the expression of the hemolysin gene, hlyA, and may promote expression of other virulence determinants in vivo. It may have both positive and negative regulator activities. | 0.453 |
folE | ndk | VC_A0616 | VC_0756 | GTP cyclohydrolase; Similar to GB:U00007 SP:P27511 GB:X63910 PID:312964 PID:405902; identified by sequence similarity; putative. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.695 |