Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
mbaAc-di-GMP phosphodiesterase A-related protein; Plays an essential role in the maintenance and the formation of the three-dimensional structure of the biofilms at the later stages of their development. Absence of mbaA promotes the accumulation of larger amount of biomass on the surfaces at later stage of development, results in the overproduction of an extracellular polymeric substance that accumulates in the matrix of biofilms. This yields biofilms lacking the typical structure consisting of pillars of cells separated by fluid filled channels. (791 aa)    
Predicted Functional Partners:
nspS
Spermidine/putrescine ABC transporter, periplasmic spermidine/putrescine-binding protein, putative; Acts as a sensor of norspermidine and enhances biofilm formation. When complexed to norspermidine, could interact with the periplasmic portion of MbaA to regulate its enzymatic activity.
     
 0.939
VC_A1083
Conserved hypothetical protein; Identified by Glimmer2; putative.
 
 
 0.921
VC_A0536
Conserved hypothetical protein; Identified by Glimmer2; putative.
 
  
 0.860
VC_0702
Conserved hypothetical protein; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
       0.849
VC_2697
GGDEF family protein; Similar to PID:576655 PID:576657; identified by sequence similarity; putative.
 
   0.803
VC_A0560
GGDEF family protein; Similar to GP:3392922; identified by sequence similarity; putative.
 
   0.802
VC_1367
GGDEF family protein; Similar to PID:633121; identified by sequence similarity; putative.
 
 
 0.801
VC_0072
Sensory box/GGDEF family protein; Similar to PID:1651932; identified by sequence similarity; putative.
 
 
0.730
VC_0705
Chorismate mutase/prephenate dehydratase; Similar to GB:L42023 SP:P43900 PID:1006481 PID:1221267 PID:1205390; identified by sequence similarity; putative.
       0.720
VC_A0785
GGDEF family protein; Similar to PID:1651932; identified by sequence similarity; putative.
 
 
0.703
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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