Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
VC_0736Isocitrate lyase; Similar to SP:P05313 GB:M20714 GB:M22621 GB:X07543 GB:X12431; identified by sequence similarity; putative. (437 aa)    
Predicted Functional Partners:
VC_0734
Malate synthase A; Similar to SP:P08997 GB:X12431 PID:396349 PID:40887 GB:U00096; identified by sequence similarity; putative; Belongs to the malate synthase family.
 
 0.999
pta
Phosphate acetyltransferase; Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family.
   
 
 0.973
VC_A0957
Malate synthase-related protein; Similar to SP:P37330 GB:X74547 PID:517247 PID:882505 GB:U00096; identified by sequence similarity; putative.
  
 
 0.951
prpB
Carboxyphosphonoenolpyruvate phosphonomutase; Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage reaction of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.
  
  
0.925
sucC
succinyl-CoA synthase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
 
 0.925
VC_0604
Aconitate hydratase 2; Similar to SP:P36683 GB:U00096 PID:2367097; identified by sequence similarity; putative; Belongs to the aconitase/IPM isomerase family.
   
 
 0.923
sucD
succinyl-CoA synthase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
   
 
 0.920
VC_0285
4-hydroxy-2-oxoglutarate aldolase/2-deydro-3-deoxyphosphogluconate aldolase; Similar to GB:L42023 PID:1004194 PID:1221953 PID:1204305 SP:P44480; identified by sequence similarity; putative.
     
 0.908
VC_0392
Aminotransferase, class V; Similar to SP:P31030 PID:164759; identified by sequence similarity; putative.
    
 0.906
VC_2504
2-hydroxyacid dehydrogenase family protein; Similar to GB:L42023 SP:P45250 PID:1007767 PID:1221703 PID:1205791; identified by sequence similarity; putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
     
 0.905
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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