STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tcpCToxin co-regulated pilus biosynthesis outer membrane protein C; Involved in TCP pilus biogenesis. (489 aa)    
Predicted Functional Partners:
tcpQ
Toxin co-regulated pilus biosynthesis protein Q; Involved in TCP pilus biogenesis.
     
 0.903
tcpE
Toxin co-regulated pilus biosynthesis protein E; Probably involved in cholera toxin receptor (GM1) interaction in order to bring the cells within close proximity of the ganglioside for efficient toxin delivery.
  
  
 0.901
tcpB
Toxin co-regulated pilus biosynthesis protein B; Involved in TCP pilus biogenesis.
     
 0.886
tcpR
Toxin co-regulated pilus biosynthesis protein R; Involved in TCP pilus biogenesis.
     
 0.881
tcpD
Toxin co-regulated pilus biosynthesis protein D; Involved in TCP pilus biogenesis.
     
 0.869
epsC
General secretion pathway protein C; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane.
  
 
 0.863
tcpT
Toxin co-regulated pilus biosynthesis protein T; Involved in the translocation of the TcpA pilin.
  
  
 0.858
tcpF
Toxin co-regulated pilus biosynthesis protein F; Involved in TCP pilus biogenesis. May be a channel protein.
     
 0.808
tcpS
Toxin co-regulated pilus biosynthesis protein S; The toxin coregulated pilus (TCP) is essential for successful colonization of the small intestine.
     
 0.802
flhB
Flagellar biosynthetic protein FlhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family.
  
 
 0.758
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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