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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tcpCToxin co-regulated pilus biosynthesis outer membrane protein C; Involved in TCP pilus biogenesis. (489 aa)    
Predicted Functional Partners:
tcpQ
Toxin co-regulated pilus biosynthesis protein Q; Involved in TCP pilus biogenesis.
     
 0.932
epsC
General secretion pathway protein C; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane.
  
 
 0.920
tcpE
Toxin co-regulated pilus biosynthesis protein E; Probably involved in cholera toxin receptor (GM1) interaction in order to bring the cells within close proximity of the ganglioside for efficient toxin delivery.
  
  
 0.876
tcpR
Toxin co-regulated pilus biosynthesis protein R; Involved in TCP pilus biogenesis.
     
 0.859
tcpD
Toxin co-regulated pilus biosynthesis protein D; Involved in TCP pilus biogenesis.
     
 0.855
tcpT
Toxin co-regulated pilus biosynthesis protein T; Involved in the translocation of the TcpA pilin.
  
  
 0.834
VC_1703
Conserved hypothetical protein; Identified by Glimmer2; putative.
    
   0.819
tcpB
Toxin co-regulated pilus biosynthesis protein B; Involved in TCP pilus biogenesis.
     
 0.804
tcpS
Toxin co-regulated pilus biosynthesis protein S; The toxin coregulated pilus (TCP) is essential for successful colonization of the small intestine.
     
 0.783
tcpF
Toxin co-regulated pilus biosynthesis protein F; Involved in TCP pilus biogenesis. May be a channel protein.
     
 0.772
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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