STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tcpSToxin co-regulated pilus biosynthesis protein S; The toxin coregulated pilus (TCP) is essential for successful colonization of the small intestine. (152 aa)    
Predicted Functional Partners:
tcpE
Toxin co-regulated pilus biosynthesis protein E; Probably involved in cholera toxin receptor (GM1) interaction in order to bring the cells within close proximity of the ganglioside for efficient toxin delivery.
     
 0.864
tcpD
Toxin co-regulated pilus biosynthesis protein D; Involved in TCP pilus biogenesis.
     
 0.845
tcpT
Toxin co-regulated pilus biosynthesis protein T; Involved in the translocation of the TcpA pilin.
     
 0.841
tcpR
Toxin co-regulated pilus biosynthesis protein R; Involved in TCP pilus biogenesis.
     
 0.829
tcpF
Toxin co-regulated pilus biosynthesis protein F; Involved in TCP pilus biogenesis. May be a channel protein.
     
 0.816
tcpQ
Toxin co-regulated pilus biosynthesis protein Q; Involved in TCP pilus biogenesis.
     
 0.789
tcpC
Toxin co-regulated pilus biosynthesis outer membrane protein C; Involved in TCP pilus biogenesis.
     
 0.783
tcpB
Toxin co-regulated pilus biosynthesis protein B; Involved in TCP pilus biogenesis.
       0.747
tcpA
Toxin co-regulated pilin; Constituent of pili, which may be involved in adhesion of V.cholerae to the host intestinal epithelium.
     
 0.597
tcpJ
Leader peptidase TcpJ; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. Processes the TcpA pilin precursor during membrane translocation.
     
 0.537
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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