STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
tcpTToxin co-regulated pilus biosynthesis protein T; Involved in the translocation of the TcpA pilin. (503 aa)    
Predicted Functional Partners:
tcpE
Toxin co-regulated pilus biosynthesis protein E; Probably involved in cholera toxin receptor (GM1) interaction in order to bring the cells within close proximity of the ganglioside for efficient toxin delivery.
 
 
 0.976
pilC
Type IV pilin biogenesis protein PilC; Involved in the translocation of the type IV pilin; Belongs to the GSP F family.
 
 
 0.969
epsF
General secretion pathway protein F; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane.
 
 
 0.965
VC_0406
MSHA biogenesis protein MshG; Similar to PID:1016255 PID:1016256; identified by sequence similarity; putative.
 
 
 0.961
tcpJ
Leader peptidase TcpJ; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. Processes the TcpA pilin precursor during membrane translocation.
 
 
 0.948
tcpR
Toxin co-regulated pilus biosynthesis protein R; Involved in TCP pilus biogenesis.
   
 
 0.928
VC_2426
Leader peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
 
 
 0.871
epsL
General secretion pathway protein L; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane.
  
 
 0.870
tcpA
Toxin co-regulated pilin; Constituent of pili, which may be involved in adhesion of V.cholerae to the host intestinal epithelium.
  
 0.860
tcpS
Toxin co-regulated pilus biosynthesis protein S; The toxin coregulated pilus (TCP) is essential for successful colonization of the small intestine.
     
 0.841
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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