Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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tcpEToxin co-regulated pilus biosynthesis protein E; Probably involved in cholera toxin receptor (GM1) interaction in order to bring the cells within close proximity of the ganglioside for efficient toxin delivery. (340 aa)    
Predicted Functional Partners:
tcpT
Toxin co-regulated pilus biosynthesis protein T; Involved in the translocation of the TcpA pilin.
 
 
 0.974
tcpC
Toxin co-regulated pilus biosynthesis outer membrane protein C; Involved in TCP pilus biogenesis.
  
  
 0.901
tcpF
Toxin co-regulated pilus biosynthesis protein F; Involved in TCP pilus biogenesis. May be a channel protein.
     
 0.868
tcpB
Toxin co-regulated pilus biosynthesis protein B; Involved in TCP pilus biogenesis.
     
 0.857
tcpS
Toxin co-regulated pilus biosynthesis protein S; The toxin coregulated pilus (TCP) is essential for successful colonization of the small intestine.
     
 0.854
tcpR
Toxin co-regulated pilus biosynthesis protein R; Involved in TCP pilus biogenesis.
     
 0.846
tcpD
Toxin co-regulated pilus biosynthesis protein D; Involved in TCP pilus biogenesis.
     
 0.843
VC_2424
Type IV pilus assembly protein PilB; Similar to GP:3220230; identified by sequence similarity; putative.
 
 
 0.831
epsE
General secretion pathway protein E; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for secretion of cholera toxin through the outer membrane.
 
 
 0.831
VC_0405
MSHA biogenesis protein MshE; Similar to PID:791156 PID:791159; identified by sequence similarity; putative.
 
 
 0.830
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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