Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
tcpFToxin co-regulated pilus biosynthesis protein F; Involved in TCP pilus biogenesis. May be a channel protein. (338 aa)    
Predicted Functional Partners:
tcpB
Toxin co-regulated pilus biosynthesis protein B; Involved in TCP pilus biogenesis.
   
 
 0.981
tcpE
Toxin co-regulated pilus biosynthesis protein E; Probably involved in cholera toxin receptor (GM1) interaction in order to bring the cells within close proximity of the ganglioside for efficient toxin delivery.
     
 0.868
tcpS
Toxin co-regulated pilus biosynthesis protein S; The toxin coregulated pilus (TCP) is essential for successful colonization of the small intestine.
     
 0.815
tcpT
Toxin co-regulated pilus biosynthesis protein T; Involved in the translocation of the TcpA pilin.
     
 0.809
tcpC
Toxin co-regulated pilus biosynthesis outer membrane protein C; Involved in TCP pilus biogenesis.
     
 0.808
tcpD
Toxin co-regulated pilus biosynthesis protein D; Involved in TCP pilus biogenesis.
     
 0.801
tcpQ
Toxin co-regulated pilus biosynthesis protein Q; Involved in TCP pilus biogenesis.
     
 0.795
tcpR
Toxin co-regulated pilus biosynthesis protein R; Involved in TCP pilus biogenesis.
     
 0.787
tcpA
Toxin co-regulated pilin; Constituent of pili, which may be involved in adhesion of V.cholerae to the host intestinal epithelium.
     
 0.735
tcpN
TCP pilus virulence regulatory protein; Probable regulatory protein for the tcp operon.
     
 0.664
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.