STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_0896Transcriptional regulator, LysR family; Similar to SP:P32064 GB:U01030 GB:X73413 PID:312766 PID:523331; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family. (306 aa)    
Predicted Functional Partners:
VC_0897
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
    0.740
VC_0732
Transcriptional regulator, LysR family; Similar to PID:887385 SP:P52667 PID:1359475; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.594
VC_2636
Transcriptional regulator, LysR family; Similar to PID:1658188; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
   
 0.570
seqA
seqA protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
  
     0.546
metJ
Met repressor; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family.
  
   
 0.532
VC_0895
Hypothetical protein; Identified by Glimmer2; putative.
       0.522
fadR
Fatty acid metabolism regulator protein; Multifunctional regulator of fatty acid metabolism.
  
  
 0.517
VC_2740
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
     0.506
VC_2040
Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the UPF0352 family.
  
     0.488
VC_1580
Transcriptional regulator, LysR family; Similar to GB:X66866 PID:403331 SP:P52692; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
   
 0.445
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.