STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_0981Conserved hypothetical protein; Identified by Glimmer2; putative. (189 aa)    
Predicted Functional Partners:
VC_0731
Antioxidant, AhpC/Tsa family; Similar to PID:965473; identified by sequence similarity; putative.
   
 
 0.741
VC_0456
HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.588
VC_1584
ankB protein; Similar to PID:563740 PID:1754534; identified by sequence similarity; putative.
    
 
 0.515
VC_2352
NupC family protein; Similar to GB:L42023 SP:P44742 PID:1003922 PID:1222453 PID:1204770; identified by sequence similarity; putative.
      
 0.508
dsbE
Thiol:disulfide interchange protein DsbE; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity); Belongs to the thioredoxin family. DsbE subfamily.
   
 
 0.507
VC_A0894
Conserved hypothetical protein; Identified by Glimmer2; putative.
 
  
 0.491
VC_0979
Oxidoreductase, short-chain dehydrogenase/reductase family; Similar to GB:U00096 SP:P77388 PID:1773175 PID:1786701; identified by sequence similarity; putative.
       0.487
VC_1367
GGDEF family protein; Similar to PID:633121; identified by sequence similarity; putative.
   
 
 0.482
VC_A0048
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
     0.472
VC_1543
Hypothetical protein; Identified by Glimmer2; putative.
    
 
 0.463
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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